+34 958 991 543 info@cloverbiosoft.com

Timeline & Changelog


May 19

Clover MSDAS v1.5 Mayor Update: Features & Improvements

  • Premium users mode is now activated. All module and features are now unlimited for premium users.
  • FT-IR data.
    • FTIR Quality Control Module: First version of QC test for FTIR data.
    • Inclusion of new default ranges and internal improvements in range selection with FTIR data.
    • FTIR Reproducibility Module: First Version of reproducibility Analysis for FTIR data.
  • Algorithms.
    • Balanced Accuracy metric at confusion matrix is now calculated and displayed in confusion matrices.
    • PCA: Edit size, color and shape of displayed dots.
  • Analysis.
    • t-test is now available in biomarker analysis as univariate analysis.
    • MALDI Biomarker Analysis Module have been redesigned.
    • SNP pairwise distance heatmap: First version of Single Nucleotide Polymorphism heatmap.
April 4

Automatic discrimination of species within the Enterobacter cloacae complex using MALDI-TOF Mass Spectrometry and supervised algorithms

January 30

Clover MSDAS v1.4 FTIR Upgrade: Features & Improvements

  • Armonisation between FTIR workflow and Clover MSDAS have been updated.
  • Rubberband algorithm has been added as Baseline correction algorithm.
  • New normalization algorithms:
    • Vector Normalization
    • Amide I Normalization
    • Amide II Normalization
  • Predefined ranges for absorbance mass filtering:
    • Membrane lipids [3000-2800]
    • Proteins [1800-1500]
    • Polysaccharides [1200-900]
January 5

Identification of Mycobacterium abscessus Subspecies by MALDI-TOF Mass Spectrometry and Machine Learning


November 28

Clover MSDAS v1.3 Features & Improvements

  • Outliers Detection Module first version release. PCA Reconstruction and Spectra Correlation analysis have been implemented.
  • Shapley Values plot includes now a bar plot to show the shapley values mean.
  • New file size upload limit is upgrade to 300MB.
  • Validation & Identification modules run now asynchronously. You can leave the screen and recover the result later.
  • Hyperparameters at classification can be now choosen manually or calculated via autotune algorithm.
  • ROC and Precision-Recall curves displayed up to 4 decimals for AUC values and can be downloaded in CSV format.
  • Error Rate have been added as a metric.
  • LightGBM have been adjusted on how hyperparameters are optimized.
  • In the ROC curve table at Biomarker Analysis module, you can click now on the table rows for selecting masses. Once they are selected, a peak matrix can be automatically generated by using those masses.
September 7

Stable version v1.0 of Clover MS Data Analysis Software


Major updates

  • Multitask mode: Now supervised classifiers run in asynchronous mode. Therefore, the user can leave or close the page/tab safely or work in other tasks, because the result will be there next time the classifier page is accessed.
  • Performance improvements: Algorithms now work in dedicated processes.
  • Random Forest: Newly optimized hyperparameters are: number of estimators, max features, max tree depth, min split size, min number of samples per leaf.
  • LightGBM: Adjustments on hyperparameters optimization. Shapley feature importances optimization.
  • Biomarker Analysis: In the ROC curve table, the user can click on the table rows for selecting masses. Once they are selected, a peak matrix can be automatically generated by using those masses as biomarkers.

Minor updates

  • TIC normalization: is now performed using the area under the entire spectrum.
  • Find Peaks Graph: The user can click on a detected peak for displaying a label with the mass value.
  • Biomarker Analysis: When a row is clicked in the ROC curve table, now it is also filtered in the Peak Distribution table.


August 28

Ultrasensitive and rapid identification of ESRI developer- and piperacillin/tazobactam-resistant Escherichia coli by the MALDIpiptaz test

July 7

Major version v0.6 LightGBM Algorithm

  • Light Gradient Boosting Machine (LightGBM) algorithm added
  • Shapley Values analysis section added in Random Forest and LightGMB algorithms
  • Confidence ellipses now can be displayed at PCA Analysis
  • SVG vector image format added. Now plots and charts can be downloaded as .svg
January 10

Major version v0.5 FTIR support

  • Fourier transform infrared (FTIR) format is now supported
  • The platform now allows work with infrared spectroscopy data in all modules
  • FTIR Specific preprocessing steps added
October 18

Minor version v0.4.5

  • ROC curves added in all modules
  • Precision-Recall curves added in all modules
July 19

Occurrence of the p019 Gene in the blaKPC-Harboring Plasmids: Adverse Clinical Impact for Direct Tracking of KPC-Producing Klebsiella pneumoniae by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

June 18

An Improved Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Data Analysis Pipeline for the Identification of Carbapenemase-Producing Klebsiella pneumoniae

June 3

Detection of azole resistance in Aspergillus fumigatus complex isolates using MALDI-TOF mass spectrometry

June 1

Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software

May 7

Video Tutorials Release


February 15

Major version v0.4 Validation Module

  • Validation Module added
    • Now all models can be validated easily
    • Results can be downloaded as .csv
    • Resulting plots can be download as images
January 24

Rapid and Reproducible MALDI-TOF-Based Method for the Detection of Vancomycin-Resistant Enterococcus faecium Using Classifying Algorithms

December 2

Implementation of MALDI-TOF Mass Spectrometry and Peak Analysis: Application to the Discrimination of Cryptococcus neoformans Species Complex and Their Interspecies Hybrids

September 28

Minor version v0.3.5 K-Nearest Neighbors

  • K- Nearest Neighbors (KNN) added
  • Neighborhood Components Analysis (NCA) added in KNN module
March 24

Minor version v0.3.5 Carbapenemases detection

  • Carbapenemases detection module added for specific institutions
  • FAQ´s section added

Contact Information | Clover Bioanalytical Software

Visit us

Phone Number

(34) 958 991 543


  • Edif. Centro de Empresas PTS.
  • Av. del Conocimiento, 41
  • 18016 Granada, Spain

Copyright © 2015 I Privacy Policy